Premium
High‐Capacity Hierarchically Imprinted Polymer Beads for Protein Recognition and Capture
Author(s) -
Nematollahzadeh Ali,
Sun Wei,
Aureliano Carla S. A.,
Lütkemeyer Dirk,
Stute Jörg,
Abdekhodaie Mohammad J.,
Shojaei Akbar,
Sellergren Börje
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004774
Subject(s) - replica , imprinting (psychology) , acrylamide , molecularly imprinted polymer , polymer , feature (linguistics) , chemistry , adsorption , computer science , nanotechnology , combinatorial chemistry , computational biology , materials science , biochemistry , copolymer , biology , organic chemistry , gene , art , catalysis , visual arts , selectivity , linguistics , philosophy
Leaving an imprint : Hierarchical protein imprinting starting from wide‐pore silica modified with a submonolayer of adsorbed protein (IgG or HSA) leads to an inverse polymeric replica of the silica template that features highly accessible protein‐complementary binding sites (see picture). The resulting poly(acrylamide) beads (PIgG or PHSA) feature high binding capacities and can be used to selectively capture the proteins HSA and IgG from blood serum.