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Regioselective Nickel‐Catalyzed Reductive Couplings of Enones and Allenes
Author(s) -
Li Wei,
Chen Nan,
Montgomery John
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004740
Subject(s) - regioselectivity , alkene , conjugate , chemistry , catalysis , complement (music) , combinatorial chemistry , nickel , coupling (piping) , reductive elimination , organic chemistry , materials science , mathematics , mathematical analysis , biochemistry , complementation , metallurgy , gene , phenotype
Alkenes made easy : In a complement to coupling processes of terminal alkynes, the reductive coupling of enones and allenes provides access to conjugate addition products that possess a 1,1‐disubstituted alkene (see scheme; cod=1,5‐cyclooctadiene). The solvent composition and reducing agent must be carefully matched to allow high levels of regioselectivity to be observed.