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A Modular, Efficient, and Stereoselective Synthesis of Substituted Piperidin‐4‐ols
Author(s) -
Cui Li,
Li Chaoqun,
Zhang Liming
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004712
Subject(s) - chemistry , library science , index (typography) , computer science , world wide web
The pied piper‐idinol of Hamelin : The one‐pot synthesis of piperidin‐4‐ols by sequential gold‐catalyzed cyclization, chemoselective reduction, and spontaneous Ferrier rearrangement has a broad substrate scope and shows excellent diastereoselectivity in the ring‐formation step. This chemistry was employed in the six‐step enantioselective synthesis of (+)‐subcosine II.
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