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Copper(II)‐Catalyzed meta‐ Selective Direct Arylation of α‐Aryl Carbonyl Compounds
Author(s) -
Duong Hung A.,
Gilligan Ruth E.,
Cooke Michael L.,
Phipps Robert J.,
Gaunt Matthew J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004704
Subject(s) - aryl , catalysis , combinatorial chemistry , chemistry , copper , metal , organic chemistry , alkyl
Strong competition : A method for the meta‐ selective arylation of the highly versatile α‐aryl carbonyl motif using diaryliodonium salts is described. In this Cu II ‐catalyzed process the remote carbonyl group is capable of overpowering even strongly para ‐directing functionalities to form the elusive meta‐ products (see scheme). Remarkably, the arylation process can also operate under metal‐free conditions.