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A Highly Para ‐Selective Copper(II)‐Catalyzed Direct Arylation of Aniline and Phenol Derivatives
Author(s) -
Ciana ClaireLise,
Phipps Robert J.,
Brandt Jochen R.,
Meyer FalcoMagnus,
Gaunt Matthew J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004703
Subject(s) - aniline , friedel–crafts reaction , phenol , catalysis , copper , combinatorial chemistry , chemistry , scheme (mathematics) , computer science , organic chemistry , mathematics , mathematical analysis
In short order : A copper‐catalyzed Friedel–Crafts‐type strategy has been developed for the title reaction. An iterative CH arylation strategy has also been demonstrated for the functionalization of anilines by sequentially delivering different aromatic groups to the para, ortho, and meta positions (see scheme, Bn=benzyl, Piv=pivaloyl).