Proof of the Existence of an Unstable Amino Acid: Pleurocybellaziridine in  Pleurocybella porrigens | Zendy

Wakimoto Toshiyuki | Zendy; Asakawa Tomohiro | Zendy; Akahoshi Saeko | Zendy; Suzuki Tomohiro | Zendy; Nagai Kaoru | Zendy; Kawagishi Hirokazu | Zendy; Kan Toshiyuki | Zendy

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Proof of the Existence of an Unstable Amino Acid: Pleurocybellaziridine in Pleurocybella porrigens

Author(s) -

Wakimoto Toshiyuki,

Asakawa Tomohiro,

Akahoshi Saeko,

Suzuki Tomohiro,

Nagai Kaoru,

Kawagishi Hirokazu,

Kan Toshiyuki

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201004646

Subject(s) - mushroom , amino acid , chemistry , stereochemistry , biology , biochemistry , food science

Angel's wing mushroom, Pleurocybella porrigens , caused fatal acute encephalopathy in Japan in 2004. The structures of cytotoxic amino acids previously isolated from the mushroom motivated a study to prove the existence of an aziridine amino acid, pleurocybellaziridine ( 1 ), found in the mushroom. The ester forms of synthetic 1 were used to confirm that the fruiting bodies contained high amounts of 1 . Furthermore, 1 showed significant toxicity towards rat oligodendrocytes.

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