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Self‐Assembled Synthetic Viral Capsids from a 24‐mer Viral Peptide Fragment
Author(s) -
Matsuura Kazunori,
Watanabe Kenta,
Matsuzaki Tsubasa,
Sakurai Kazuo,
Kimizuka Nobuo
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004606
Subject(s) - fragment (logic) , capsid , virology , peptide , biology , chemistry , virus , computer science , biochemistry , algorithm
Assemble a virus : A chemical strategy to de novo design “tailor‐made” viruslike nanocapsules was developed (see picture). 24‐mer β‐annulus peptides of the tomato bushy stunt virus (TBSV) spontaneously self‐assemble into hollow nanocapsules with a size of 30–50 nm. The hollow structure of the assemblies was clearly revealed by small‐angle X‐ray scattering (SAXS).