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Inside Cover: Synchronized Synthesis of Peptide‐Based Macrocycles by Digital Microfluidics (Angew. Chem. Int. Ed. 46/2010)
Author(s) -
Jebrail Mais J.,
Ng Alphonsus H. C.,
Rai Vishal,
Hili Ryan,
Yudin Andrei K.,
Wheeler Aaron R.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004588
Subject(s) - microfluidics , cover (algebra) , digital microfluidics , reagent , peptide , nanotechnology , ring (chemistry) , materials science , electrode , chemistry , combinatorial chemistry , optoelectronics , organic chemistry , engineering , biochemistry , mechanical engineering , electrowetting
A microfluidic technique for synchronized chemical synthesis has been developed and applied to the formation of peptide‐based macrocycles and analogues with side chains appended during ring‐opening. A. R. Wheeler and co‐workers describe this digital microfluidic technique, in which discrete droplets of samples and reagents are controlled by electric potentials applied to an array of electrodes coated with a hydrophobic insulator, in their Communication on page 8625 ff. Artwork: M. Jebrail/S. Youhanna.