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Asymmetric Intermolecular Hydroamination of Unactivated Alkenes with Simple Amines
Author(s) -
Reznichenko Alexander L.,
Nguyen Hiep N.,
Hultzsch Kai C.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004570
Subject(s) - hydroamination , stereocenter , intermolecular force , markovnikov's rule , simple (philosophy) , chemistry , combinatorial chemistry , computer science , organic chemistry , catalysis , enantioselective synthesis , philosophy , molecule , epistemology , regioselectivity
A hard nut to crack : The asymmetric intermolecular Markovnikov addition of simple amines to unactivated alkenes can be achieved utilizing binaphtholate rare‐earth‐metal catalysts with up to 61 % ee and 73 % de in the case where R 2 contains a stereogenic center.