Premium
Activating Platinum Anticancer Complexes with Visible Light
Author(s) -
BernersPrice Susan J.
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004552
Subject(s) - platinum , chemistry , ligand (biochemistry) , pyridine , visible spectrum , stereochemistry , cytotoxic t cell , platinum compounds , substitution (logic) , combinatorial chemistry , medicinal chemistry , materials science , biochemistry , receptor , in vitro , catalysis , optoelectronics , computer science , programming language
The next generation : Classical Pt II anticancer compounds contain cis diam(m)ine ligands and are activated by ligand‐substitution reactions. Pt IV diam(m)ine diazido dihydroxo complexes are nontoxic to cells until activated by light. Replacement of the diam(m)ine ligands in a trans configuration by pyridine gives a complex that is potently cytotoxic when irradiated with visible light and which has potential as a photochemotherapeutic agent.