Premium
Organocatalytic Asymmetric Sulfa‐Michael/Michael Addition Reactions: A Strategy for the Synthesis of Highly Substituted Chromans with a Quaternary Stereocenter
Author(s) -
Wang XuFan,
Hua QiuLin,
Cheng Ying,
An XiaoLei,
Yang QingQing,
Chen JiaRong,
Xiao WenJing
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004534
Subject(s) - stereocenter , bifunctional , michael reaction , yield (engineering) , enantiomer , computer science , chemistry , combinatorial chemistry , organic chemistry , catalysis , enantioselective synthesis , materials science , metallurgy
Simply complex : Diverse and structurally complex chroman derivatives with a quaternary stereocenter have been obtained through the titled reaction of thiols with nitroolefin enoates using the bifunctional catalyst 1 . The reaction features simple experimental procedures, high yield, enantiomeric excess, and excellent diastereoselectivity.