Premium
Noncovalent DNA‐Binding Metallo‐Supramolecular Cylinders Prevent DNA Transactions in vitro
Author(s) -
Ducani Cosimo,
Leczkowska Anna,
Hodges Nikolas J.,
Han Michael J.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004471
Subject(s) - dna , supramolecular chemistry , dna clamp , dna polymerase , chemistry , biophysics , dna replication , dna polymerase ii , in vitro , microbiology and biotechnology , molecule , biochemistry , biology , polymerase chain reaction , gene , reverse transcriptase , organic chemistry
Supramolecular metal cylinders not only bind noncovalently to DNA inducing substantial coiling but are able to recognize specific DNA structures involved in biological processes as DNA replication. It is demonstrated that these molecules can inhibit the amplification of the DNA mediated by a Taq DNA polymerase and are even able to displace the enzyme from a double strand DNA (see scheme).