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Combining Independent Drug Classes into Superior, Synergistically Acting Hybrid Molecules
Author(s) -
MüllerSchiffmann Andreas,
MärzBerberich Julia,
Andreyeva Aksana,
Rönicke Raik,
Bartnik Dirk,
Brener Oleksandr,
Kutzsche Janine,
Horn Anselm H. C.,
Hellmert Marco,
Polkowska Jolanta,
Gottmann Kurt,
Reymann Klaus G.,
Funke S. Aileen,
NagelSteger Luitgart,
Moriscot Christine,
Schoehn Guy,
Sticht Heinrich,
Willbold Dieter,
Schrader Thomas,
Korth Carsten
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004437
Subject(s) - moiety , selection (genetic algorithm) , enantiomer , computer science , rational design , chemistry , drug , combinatorial chemistry , computational biology , stereochemistry , nanotechnology , artificial intelligence , biology , pharmacology , materials science
More than the sum of its parts : Novel hybrid compounds consisting of an organic β‐sheet‐breaking moiety and a signaling, D ‐enantiomeric Aβ‐recognizing peptide moiety have been designed (see picture). The compounds, which were chemically synthesized and characterized by several techniques, combine rational design and drug selection from libraries and inhibit Aβ oligomerization and Aβ‐induced synaptic pathology.