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Enantioselective Synthesis of 4‐Hydroxy‐2‐cyclohexenones through a Multicomponent Cyclization
Author(s) -
Barluenga José,
Suero Marcos G.,
De la Campa Raquel,
Flórez Josefa
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004413
Subject(s) - enantioselective synthesis , reagent , chromium , lithium (medication) , combinatorial chemistry , chemistry , carbene , computer science , organic chemistry , catalysis , psychology , psychiatry
Three metal cooperation promotes the one‐pot selective coupling of a chromium carbene complex, an imide lithium enolate, and a propargylic organomagnesium reagent giving access to novel and densely functionalized 4‐allenyl‐2‐cyclohexenones (see scheme). These useful synthetic intermediates have been prepared through a cyclization process that involves newly reported reaction steps and an unusually high level of asymmetric induction.