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“Illusionary” Polymerase Activity Triggered by Metal Ions: Use for Molecular Logic‐Gate Operations
Author(s) -
Park Ki Soo,
Jung Cheulhee,
Park Hyun Gyu
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004406
Subject(s) - polymerase , selection (genetic algorithm) , construct (python library) , metal ions in aqueous solution , dna polymerase beta , polymerase chain reaction , chemistry , dna polymerase , ion , computer science , combinatorial chemistry , computational biology , biochemistry , enzyme , dna , gene , biology , programming language , artificial intelligence , organic chemistry , dna damage , base excision repair
Metal ion, an astonishing illusionist : In a new concept, “illusionary” polymerase activity is intentionally triggered at T–T and C–C mismatched primers by Hg 2+ and Ag + ions, respectively. A novel strategy to construct molecular‐scale logic gates utilizes the nonnatural polymerase activity induced by the metal ions by rational design of the primers and selection of the type of DNA polymerase (see picture).