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Signal‐Enhanced Liquid‐Crystal DNA Biosensors Based on Enzymatic Metal Deposition
Author(s) -
Tan Hui,
Yang Shengyuan,
Shen Guoli,
Yu Ruqin,
Wu Zhaoyang
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004272
Subject(s) - homeotropic alignment , biosensor , deposition (geology) , materials science , birefringence , liquid crystal , substrate (aquarium) , nanotechnology , chemical engineering , optoelectronics , optics , paleontology , oceanography , physics , engineering , sediment , geology , biology
No cloudiness with a silver lining : Deposition of metallic silver on a liquid‐crystal substrate with attached DNA strands greatly alters the surface topology and induces a homeotropic‐to‐tiled transition of the LC molecules surrounding them, resulting in an obvious change in appearance from dark to birefringent (see picture; Ag: spheres). This enzymatic silver deposition is an excellent signal‐enhancement strategy for LC optical amplification.