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The Third Hydrogenase: A Ferracyclic Carbamoyl with Close Structural Analogy to the Active Site of Hmd
Author(s) -
Turrell Peter J.,
Wright Joseph A.,
Peck Jamie N. T.,
Oganesyan Vasily S.,
Pickett Christopher J.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004189
Subject(s) - heterolysis , active site , chemistry , stereochemistry , hydrogenase , substituent , computer science , crystallography , biochemistry , enzyme , catalysis
Natural model : The synthesis of a close structural analogue of the active site of [Fe]‐hydrogenase is described (see structure; C gray, H dark blue, Fe green, N light blue, O red, S yellow). Nature most probably constructs the five membered ferracyclic ring to poise the 2‐hydroxy pyridine substituent in a position to assist the heterolytic cleavage of dihydrogen, and the accessibility of the analogue should now provide opportunities for probing this.