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Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase
Author(s) -
Maid Harald,
Böhm Philipp,
Huber Stefan M.,
Bauer Walter,
Hummel Werner,
Jux Norbert,
Gröger Harald
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004101
Subject(s) - cofactor , nad+ kinase , catalysis , chemistry , porphyrin , enzyme , enzyme catalysis , combinatorial chemistry , oxidase test , redox , photochemistry , organic chemistry
An enzyme substitute : A synthetic Fe III porphyrin was used as a catalyst for the activation and reduction of O 2 into H 2 O with the cofactor NAD(P)H in aqueous solution. The catalyst is compatible with different preparative enzymatic oxidation reactions. Thus, a new method is provided for the in situ regeneration of the oxidized cofactor NAD(P) + with help from a non‐enzymatic, synthetic catalyst (see scheme).