Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase | Zendy

Maid Harald | Zendy; Böhm Philipp | Zendy; Huber Stefan M. | Zendy; Bauer Walter | Zendy; Hummel Werner | Zendy; Jux Norbert | Zendy; Gröger Harald | Zendy

Premium

Iron Catalysis for In Situ Regeneration of Oxidized Cofactors by Activation and Reduction of Molecular Oxygen: A Synthetic Metalloporphyrin as a Biomimetic NAD(P)H Oxidase

Author(s) -

Maid Harald,

Böhm Philipp,

Huber Stefan M.,

Bauer Walter,

Hummel Werner,

Jux Norbert,

Gröger Harald

Publication year - 2011

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201004101

Subject(s) - cofactor , nad+ kinase , catalysis , chemistry , porphyrin , enzyme , enzyme catalysis , combinatorial chemistry , oxidase test , redox , photochemistry , organic chemistry

An enzyme substitute : A synthetic Fe III porphyrin was used as a catalyst for the activation and reduction of O 2 into H 2 O with the cofactor NAD(P)H in aqueous solution. The catalyst is compatible with different preparative enzymatic oxidation reactions. Thus, a new method is provided for the in situ regeneration of the oxidized cofactor NAD(P) + with help from a non‐enzymatic, synthetic catalyst (see scheme).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research