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Cascade Palladium‐Catalyzed Direct Intramolecular Arylation/Alkene Isomerization Sequences: Synthesis of Indoles and Benzofurans
Author(s) -
Yagoubi Myriam,
Cruz Ana C. F.,
Nichols Paula L.,
Elliott Richard L.,
Willis Michael C.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004097
Subject(s) - intramolecular force , alkene , isomerization , palladium , chemistry , catalysis , cascade , cascade reaction , combinatorial chemistry , divergent synthesis , organic chemistry , chromatography
One route, two cycles : A palladium‐catalyzed intramolecular direct arylation reaction combined with an isomerization step provided a straightforward synthetic route to both indoles and benzofurans (see scheme). Isolation and functionalization of intermediate alkene isomers allowed the formation of variants having substituents remote from the core.