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Catalytic Asymmetric Direct Henry Reaction of Ynals: Short Syntheses of (2 S ,3 R )‐(+)‐Xestoaminol C and (−)‐Codonopsinines
Author(s) -
Uraguchi Daisuke,
Nakamura Shinji,
Ooi Takashi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004072
Subject(s) - catalysis , stereoselectivity , triple bond , chemistry , nitro , combinatorial chemistry , organic chemistry , double bond , alkyl
Triple for all : Various optically active anti ‐β‐nitro propargylic alcohols are synthesized by the catalytic stereoselective addition of nitroalkanes to ynals (the direct Henry reaction of ynals). The utilization of the rich chemistry of carbon–carbon triple bond allows rapid access to three natural products.