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A Temperature‐Sensitive Drug Release System Based on Phase‐Change Materials
Author(s) -
Choi SungWook,
Zhang Yu,
Xia Younan
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004057
Subject(s) - dextran , colloid , melting temperature , phase change , materials science , melting point , colloidal particle , chemical engineering , phase (matter) , phase transition , nanotechnology , chemistry , chromatography , thermodynamics , composite material , organic chemistry , physics , engineering
Melting away : Phase‐change materials (PCMs) are used to encapsulate colloidal particles with FITC‐dextran to demonstrate a new temperature‐sensitive drug release system. As the temperature is increased to the melting point of the PCM, the particles leach out, followed by release of FITC‐dextran. The initiation and rate of release can be manipulated by using different combinations of materials for the PCM and colloidal particles.