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Primary and Secondary Aminophosphines as Novel P‐Stereogenic Building Blocks for Ligand Synthesis
Author(s) -
Revés Marc,
Ferrer Catalina,
León Thierry,
Doran Sean,
Etayo Pablo,
VidalFerran Anton,
Riera Antoni,
Verdaguer Xavier
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004041
Subject(s) - stereocenter , chirality (physics) , ligand (biochemistry) , chemistry , reactivity (psychology) , stereochemistry , organic chemistry , physics , enantioselective synthesis , medicine , biochemistry , receptor , catalysis , chiral symmetry breaking , alternative medicine , pathology , quantum mechanics , quark , nambu–jona lasinio model
Set the N free! The reactivity of the amino group of P‐stereogenic aminophosphines allows the further elaboration of the aminophosphine unit whilst preserving the original chirality of the phosphorus atom (see picture; Rh green). P‐stereogenic aminodiphosphine ligands can easily be prepared in optically pure forms, feature distinct structural and electronic characteristics, and can be used in asymmetric hydrogenation reactions.