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Triggered Templated Assembly of Protein Polymersomes
Author(s) -
Li Feng,
de Wolf Frits A.,
Marcelis Antonius T. M.,
Sudhölter Ernst J. R.,
Cohen Stuart Martien A.,
Leermakers Frans A. M.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201004003
Subject(s) - polymersome , copolymer , vesicle , nanotechnology , biocompatible material , poloxamer , template , chemistry , computer science , materials science , polymer science , amphiphile , biochemistry , polymer , engineering , membrane , organic chemistry , biomedical engineering
Trigger the block : Stable biocompatible protein polymersomes can be generated by a triggered templated self‐assembly route (see picture). Pluronic L121 vesicles (red core with blue corona) take up a biosynthetic triblock copolymer CS X S X C into their unilamellar shell. In response to changes in pH (trigger), the S block becomes hydrophobic and adapts to the template vesicle, thus directing the formation of protein polymersomes.