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Cover Picture: RNA Dynamics by Design: Biasing Ensembles Towards the Ligand‐Bound State (Angew. Chem. Int. Ed. 33/2010)
Author(s) -
Stelzer Andrew C.,
Kratz Jeremy D.,
Zhang Qi,
AlHashimi Hashim M.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003852
Subject(s) - transactivation , rna , cover (algebra) , rational design , ligand (biochemistry) , molecular dynamics , chemistry , int , dynamics (music) , computational biology , physics , nanotechnology , statistical physics , computational chemistry , computer science , biology , materials science , engineering , biochemistry , transcription factor , mechanical engineering , receptor , acoustics , operating system , gene
The rational design of biomolecular structures with prescribed dynamic properties is an outstanding challenge in structural biology. In their Communication on page 5731 ff., H. M. Al‐Hashimi and co‐workers use a single A‐U to G‐C mutation to rationally alter the dynamic characteristics of the transactivation response element (TAR) RNA so that it mimics its bound state with the ligand argininamide. A thermodynamic topological framework emerges for designing local and global aspects of RNA dynamics at atomic resolution.