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Programmed Nanoparticle Aggregation Using Molecular Beacons
Author(s) -
Lovell Jonathan F.,
Jin Honglin,
Ng Kenneth K.,
Zheng Gang
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003846
Subject(s) - beacon , molecular beacon , nanoparticle , nanotechnology , computer science , chemistry , dna , materials science , biochemistry , telecommunications , oligonucleotide
Out in the open : Hydrophobically modified molecular beacons were inserted into lipid nanoparticles. Upon addition of the target DNA to a solution of the lipid nanoparticles, irreversible nanoparticle aggregation occurred (see picture). This aggregation phenomenon results from the opening of the molecular beacons.