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Synthesis of 5‐Substituted 1 H ‐Tetrazoles from Nitriles and Hydrazoic Acid by Using a Safe and Scalable High‐Temperature Microreactor Approach
Author(s) -
Gutmann Bernhard,
Roduit JeanPaul,
Roberge Dominique,
Kappe C. Oliver
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003733
Subject(s) - hydrazoic acid , microreactor , scalability , chemistry , explosive material , flow chemistry , process engineering , computer science , database , organic chemistry , catalysis , engineering
Harnessing hydrazoic acid in a microreactor! Tetrazoles have been synthesized in a very efficient manner by using a high‐temperature/high‐pressure process intensification regime. Despite the toxic and explosive nature of hydrazoic acid, the synthesis was conducted safely in continuous flow format with residence times as short as 2.5 minutes at 260 °C (see picture).