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Copper‐Catalyzed Rearrangement of Tertiary Amines through Oxidation of Aliphatic CH Bonds in Air or Oxygen: Direct Synthesis of α‐Amino Acetals
Author(s) -
Tian JieSheng,
Loh TeckPeng
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003646
Subject(s) - tetramethylethylenediamine , chemistry , catalysis , copper , oxygen , photochemistry , mechanism (biology) , reaction mechanism , isotopic labeling , oxygen atom , medicinal chemistry , polymer chemistry , organic chemistry , molecule , philosophy , epistemology
A surprising turn of events : Mechanistic studies, including trapping, control, and isotope‐labeling experiments, led to the proposal of a rearrangement mechanism involving oxidation of aliphatic CH bonds (see scheme; TMEDA=tetramethylethylenediamine).