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Reversible pH‐Regulated Control of Photosensitized Singlet Oxygen Production Using a DNA i‐Motif
Author(s) -
Tørring Thomas,
Toftegaard Rasmus,
Arnbjerg Jacob,
Ogilby Peter R.,
Gothelf Kurt V.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003612
Subject(s) - singlet oxygen , motif (music) , photochemistry , chemistry , oxygen , singlet state , dna , biochemistry , organic chemistry , physics , acoustics , nuclear physics , excited state
On again, off again : Reversible pH‐controlled on‐and‐off switching of a singlet oxygen sensitizer is achieved when an i‐motif DNA sequence is employed to control the proximity of a singlet oxygen sensitizer and a quencher (see picture). At pH values less than 5, the i‐motif is stable and the singlet oxygen sensitizer quenched, whereas at pH values above 8 the i‐motif is denatured and singlet oxygen production is increased by a factor of 35.
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