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A Versatile DNA Nanochip for Direct Analysis of DNA Base‐Excision Repair
Author(s) -
Endo Masayuki,
Katsuda Yousuke,
Hidaka Kumi,
Sugiyama Hiroshi
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003604
Repair kit : The single DNA‐repair enzymes 8‐oxoguanine glycosylase and T4 pyrimidine dimer glycosylase were analyzed by a nanoscale DNA chip containing two double‐stranded DNA molecules (see picture). Dynamic movement of the enzymes and the single DNA‐repair reaction on the DNA nanochip was visualized by fast‐scanning atomic force microscopy.