Enantioselective and  Z / E ‐Selective Conjugate Addition of α‐Substituted Cyanoacetates to Acetylenic Esters Catalyzed by Bifunctional Ruthenium and Iridium Complexes | Zendy

Hasegawa Yasuharu | Zendy; Gridnev Ilya D. | Zendy; Ikariya Takao | Zendy

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Enantioselective and Z / E ‐Selective Conjugate Addition of α‐Substituted Cyanoacetates to Acetylenic Esters Catalyzed by Bifunctional Ruthenium and Iridium Complexes

Author(s) -

Hasegawa Yasuharu,

Gridnev Ilya D.,

Ikariya Takao

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201003585

Subject(s) - iridium , bifunctional , enantioselective synthesis , ruthenium , chemistry , catalysis , enantiomer , conjugate , adduct , stereoselectivity , combinatorial chemistry , stereochemistry , organic chemistry , medicinal chemistry , mathematics , mathematical analysis

Metal‐based catalysts : The title reaction provided the chiral adducts in high yields, excellent enantiomeric excess, and high Z / E selectivity. A combined NMR/DFT study revealed a key intermediate for the stereoselective reaction and a possible reaction mechanism (see the optimized transition‐state structure).

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