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Trapping Unstable Benzoquinone Analogues by Coordination to a [(η 5 ‐C 5 Me 5 )Ir] Fragment and the Anticancer Activity of the Resulting Complexes
Author(s) -
Hartinger Christian G.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003565
Subject(s) - moiety , chemistry , trapping , stereochemistry , group 2 organometallic chemistry , in vitro , benzoquinone , crystallography , molecule , biochemistry , organic chemistry , biology , ecology
Gotcha! Unstable dithio‐ and diselenobenzoquinones can be trapped by coordination to an [(η 5 ‐C 5 Me 5 )Ir] moiety (see structure; gray C, white H, pink Ir, yellow Se). In vitro investigations on the anticancer activity of the resulting complexes showed them to be comparable to cis ‐platin. These organometallic species could form the basis for new anticancer agents.