Rhodium(II)‐Catalyzed One‐Pot Four‐Component Synthesis of Functionalized Polyether Macrocycles at High Concentration | Zendy

Zeghida Walid | Zendy; Besnard Céline | Zendy; Lacour Jérôme | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Rhodium(II)‐Catalyzed One‐Pot Four‐Component Synthesis of Functionalized Polyether Macrocycles at High Concentration

Author(s) -

Zeghida Walid,

Besnard Céline,

Lacour Jérôme

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201003559

Subject(s) - rhodium , catalysis , component (thermodynamics) , chemistry , polymer chemistry , combinatorial chemistry , organic chemistry , physics , thermodynamics

Against conventional wisdom , the rhodium(II)‐catalyzed nontemplated macrocyclization of four separate components in one reaction vessel became more efficient as the concentration was increased. Thus, α‐diazo‐β‐ketoesters underwent condensation with 1,4‐dioxane, tetrahydrofuran, or tetrahydropyran as the solvent to yield 16‐ to 18‐membered polyether macrocycles in up to 75 % yield (see scheme; R=Me, Et, PhCH 2 CH 2 , allyl, PhCHCH 2 ).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research