tmp 4 Zr: An Atom‐Economical Base for the Metalation of Functionalized Arenes and Heteroarenes | Zendy

Jeganmohan Masilamani | Zendy; Knochel Paul | Zendy

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tmp 4 Zr: An Atom‐Economical Base for the Metalation of Functionalized Arenes and Heteroarenes

Author(s) -

Jeganmohan Masilamani,

Knochel Paul

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201003558

Subject(s) - metalation , chemistry , zirconium , transition metal , lithium (medication) , lithium atom , reactivity (psychology) , main group element , base (topology) , ring (chemistry) , combinatorial chemistry , metal , organic chemistry , polymer chemistry , catalysis , ion , mathematical analysis , mathematics , medicine , alternative medicine , pathology , ionization , endocrinology

Zirconium bases reach lots of places : Only 25 % of zirconium metal is required for the metalation of various functionalized aromatic compounds and heterocycles. All four 2,2,6,6‐tetramethylpiperidyl (tmp) groups of the new base tmp 4 Zr⋅4 MgCl 2 ⋅6 LiCl ( 1 ) are used up in the metalation process. The resulting zirconium species smoothly undergo palladium‐catalyzed cross‐couplings and addition to CO 2 and epoxides (see scheme).

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