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Palladium‐Catalyzed β Arylation of Carboxylic Esters
Author(s) -
Renaudat Alice,
JeanGérard Ludivine,
Jazzar Rodolphe,
Kefalidis Christos E.,
Clot Eric,
Baudoin Olivier
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003544
Subject(s) - palladium , catalysis , substituent , halide , aryl , chemistry , enantiomer , carboxylic acid , organic chemistry , medicinal chemistry , combinatorial chemistry , alkyl
Alter ego : In the presence of an appropriate palladium(0) catalyst, carboxylic esters underwent β arylation instead of the more common α‐arylation reaction with aryl halides containing an ortho electronegative substituent (see scheme; Cy=cyclohexyl). An asymmetric version of the reaction gave the product with an enantiomeric ratio of up to 77:23.
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