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Asymmetric Total Synthesis of Cylindrocyclophanes A and F through Cyclodimerization and a Ramberg–Bäcklund Reaction
Author(s) -
Nicolaou K. C.,
Sun YaPing,
Korman Henry,
Sarlah David
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003500
Subject(s) - chemistry , stereochemistry
Two make a cycle : A Ramberg–Bäcklund reaction was employed to form the macrocyclic carbon skeleton of the marine natural products cylindrocyclophanes A and F in an asymmetric synthesis through a head‐to‐tail dimerization approach (see scheme).
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