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Specific Recognition of Proteins by Array‐Bound Hexanucleotides
Author(s) -
Mescalchin Alessandra,
Wünsche Winfried,
Sczakiel Georg
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003462
Subject(s) - computational biology , human immunodeficiency virus (hiv) , sequence (biology) , consensus sequence , biology , computer science , chemistry , genetics , base sequence , gene , virology
Maximum information density : The complete hexanucleotide sequence space can be immobilized on a chip. The binding of a number of proteins was profiled with this array of 4096 sequences, including fluorescently labeled forms of the HIV‐2 and HIV‐1 reverse transciptases (the consensus motif is shown in the picture). This new technique should aid in the search for pharmaceutical lead compunds.