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Ligand‐Clustered “Patchy” Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting
Author(s) -
Poon Zhiyong,
Chen Shujun,
Engler Amanda C.,
Lee Hyungil,
Atas Evrim,
von Maltzahn Geoffrey,
Bhatia Sangeeta N.,
Hammond Paula T.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003445
Subject(s) - nanoparticle , ligand (biochemistry) , construct (python library) , in vivo , presentation (obstetrics) , nanotechnology , computer science , variable (mathematics) , biophysics , chemistry , computational biology , biology , materials science , biochemistry , mathematics , medicine , genetics , receptor , programming language , mathematical analysis , radiology
A matter of presentation : The manner in which polyvalent ligands are presented to a cell—homogeneously or in spatially defined groupings on a nanoparticle surface—may play an important role in cellular uptake. This aspect is investigated for the first time using a linear dendritic polymer construct to pattern the surfaces of nanoparticles with variable‐sized ligand clusters in different spatial arrangements.