Identification of a Nonaketide Product for the Iterative Polyketide Synthase in Biosynthesis of the Nine‐Membered Enediyne C‐1027 | Zendy

Chen Xiaolei | Zendy; Guo ZuFeng | Zendy; Lai Pok Man | Zendy; Sze Kong Hung | Zendy; Guo Zhihong | Zendy

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Identification of a Nonaketide Product for the Iterative Polyketide Synthase in Biosynthesis of the Nine‐Membered Enediyne C‐1027

Author(s) -

Chen Xiaolei,

Guo ZuFeng,

Lai Pok Man,

Sze Kong Hung,

Guo Zhihong

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201003369

Subject(s) - enediyne , polyketide synthase , thioesterase , atp synthase , biosynthesis , polyketide , stereochemistry , chemistry , biochemistry , product (mathematics) , enzyme , biology , mathematics , geometry

Not octa‐ but nonaketide : The nine‐membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A.

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