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Identification of a Nonaketide Product for the Iterative Polyketide Synthase in Biosynthesis of the Nine‐Membered Enediyne C‐1027
Author(s) -
Chen Xiaolei,
Guo ZuFeng,
Lai Pok Man,
Sze Kong Hung,
Guo Zhihong
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003369
Subject(s) - enediyne , polyketide synthase , thioesterase , atp synthase , biosynthesis , polyketide , stereochemistry , chemistry , biochemistry , product (mathematics) , enzyme , biology , mathematics , geometry
Not octa‐ but nonaketide : The nine‐membered enediyne core polyketide synthase SgcE efficiently synthesizes a nonaketide in the absence of any assisting proteins (see scheme), contrary to the suggestion that an octaketide is the product of the synthase under assistance from a thioesterase. This finding redefines the catalytic functions of the polyketide synthase. CoA=coenzyme A.