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Concise Synthesis of Tetrahydropyrans by a Tandem Oxa‐Michael/Tsuji–Trost Reaction
Author(s) -
Wang Liang,
Li Pengfei,
Menche Dirk
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003304
Subject(s) - stereocenter , domino , tandem , sequence (biology) , cascade reaction , computer science , chemistry , enantioselective synthesis , organic chemistry , catalysis , materials science , biochemistry , composite material
A novel domino sequence facilitates the rapid assembly of polysubstituted tetrahydropyrans. The one‐pot relay process generates up to three new stereogenic centers, including a tetrasubstituted carbon center, in a highly concise and convergent fashion from simple starting materials.
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