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Enzyme Reaction in the Pores of CaCO 3 Particles upon Ultrasound Disruption of Attached Substrate‐Filled Liposomes
Author(s) -
Yashchenok Alexey M.,
Delcea Mihaela,
Videnova Kristina,
JaresErijman Elizabeth A.,
Jovin Thomas M.,
Konrad Manfred,
Möhwald Helmuth,
Skirtach Andre G.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003244
Subject(s) - substrate (aquarium) , peroxidase , liposome , enzyme , adsorption , chemistry , combinatorial chemistry , chemical engineering , materials science , nanotechnology , biochemistry , biology , organic chemistry , ecology , engineering
Breaking out : Liposomes that are adsorbed onto porous CaCO 3 particles and that contain the peroxidase substrate Amplex Red (AR) are disrupted by ultrasonic treatment. The substrate is released and diffuses into the inner part of the multicompartment containers where the peroxidase enzyme is found, and the enzymatic reaction is triggered. This approach may be useful for the simultaneous delivery of multiple molecules into cells.