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Cisplatin: Polymorphism and Structural Insights into an Important Chemotherapeutic Drug
Author(s) -
Ting Valeska P.,
Schmidtmann Marc,
Wilson Chick C.,
Weller Mark T.
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003185
Subject(s) - cisplatin , intermolecular force , drug , polymorphism (computer science) , hydrogen bond , chemistry , crystallography , computer science , stereochemistry , medicine , combinatorial chemistry , pharmacology , molecule , chemotherapy , gene , biochemistry , genotype , organic chemistry , surgery
The changing face of cisplatin : The complete crystal structures, including the details of extensive intermolecular hydrogen bonding in two enantiotropic polymorphs of the chemotherapeutic drug cisplatin, have been elucidated. A massive thermal hysteresis effect exists between the two polymorphs, α and β, that are active at ambient temperatures.