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Role of the Conformational Rigidity in the Design of Biomimetic Antimicrobial Compounds
Author(s) -
Ivankin Andrey,
Livne Liran,
Mor Amram,
Caputo Gregory A.,
DeGrado William F.,
Meron Mati,
Lin Binhua,
Gidalevitz David
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003104
Subject(s) - antimicrobial , rigidity (electromagnetism) , membrane , structural rigidity , chemistry , flexibility (engineering) , nanotechnology , antimicrobial peptides , biophysics , materials science , organic chemistry , biochemistry , biology , engineering , composite material , statistics , mathematics , structural engineering
When structural flexibility is a plus : A link between structural flexibility of biomimetic antimicrobials and their ability to penetrate into the hydrophobic core and disrupt the integrity of bacterial lipid model membranes has been established using liquid surface X‐ray scattering techniques. Results indicate that the modes of interaction of flexible and conformationally restrained antimicrobials with the bacterial membranes are different (see picture).