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A Bimetallic Titanium Catalyst for the Enantioselective Cyanation of Aldehydes Based on Cooperative Catalysis
Author(s) -
North Michael
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201003014
Subject(s) - cyanation , cyanohydrin , trimethylsilyl cyanide , catalysis , bimetallic strip , enantioselective synthesis , cyanide , acetic anhydride , sodium cyanide , titanium , chemistry , organic chemistry
Joined at the hip : By linking two salen ligands together with a strap of appropriate size and shape, the effectiveness of a bimetallic titanium(salen) complex as a catalyst for asymmetric cyanohydrin synthesis can be increased by up to two orders of magnitude. The optimal catalyst is active at a catalyst loading as low as 0.0005 mol % and will accept both trimethylsilyl cyanide and sodium cyanide/acetic anhydride as the cyanide source (see scheme).