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A Versatile Palladium/Triphosphane System for Direct Arylation of Heteroarenes with Chloroarenes at Low Catalyst Loading
Author(s) -
Roy David,
Mom Sophal,
Beaupérin Matthieu,
Doucet Henri,
Hierso JeanCyrille
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002987
Subject(s) - catalysis , palladium , bromide , ring (chemistry) , chemistry , combinatorial chemistry , dimethylacetamide , medicinal chemistry , computer science , organic chemistry , solvent
Put a ring on it : The use of an air‐stable, robust palladium/tridentate phosphane catalyst in direct CH and CCl activation reactions is reported (see scheme; DMAc= N , N ‐dimethylacetamide, TBAB=tetra‐ n ‐butylammonium bromide). Electron‐rich, electron‐poor, and polysubstituted furans (X=O), thiophenes (X=S), pyrroles (X=NR 5 ), and thiazoles were arylated with chloroarenes in the presence of the catalyst.