A Versatile Palladium/Triphosphane System for Direct Arylation of Heteroarenes with Chloroarenes at Low Catalyst Loading | Zendy

Roy David | Zendy; Mom Sophal | Zendy; Beaupérin Matthieu | Zendy; Doucet Henri | Zendy; Hierso JeanCyrille | Zendy

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A Versatile Palladium/Triphosphane System for Direct Arylation of Heteroarenes with Chloroarenes at Low Catalyst Loading

Author(s) -

Roy David,

Mom Sophal,

Beaupérin Matthieu,

Doucet Henri,

Hierso JeanCyrille

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002987

Subject(s) - catalysis , palladium , bromide , ring (chemistry) , chemistry , combinatorial chemistry , dimethylacetamide , medicinal chemistry , computer science , organic chemistry , solvent

Put a ring on it : The use of an air‐stable, robust palladium/tridentate phosphane catalyst in direct CH and CCl activation reactions is reported (see scheme; DMAc= N , N ‐dimethylacetamide, TBAB=tetra‐ n ‐butylammonium bromide). Electron‐rich, electron‐poor, and polysubstituted furans (X=O), thiophenes (X=S), pyrroles (X=NR 5 ), and thiazoles were arylated with chloroarenes in the presence of the catalyst.

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