Premium
PEGylated Inorganic Nanoparticles
Author(s) -
Karakoti Ajay S.,
Das Soumen,
Thevuthasan Suntharampillai,
Seal Sudipta
Publication year - 2011
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002969
Subject(s) - pegylation , polyethylene glycol , surface modification , peg ratio , nanomaterials , nanotechnology , nanoparticle , materials science , chemistry , chemical engineering , organic chemistry , engineering , finance , economics
Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long‐term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides “stealth” characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure‐directing agent in synthesis of oxides is also presented.