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Metal‐Free Direct Asymmetric Aminoxylation of Aldehydes Catalyzed by a Binaphthyl‐Based Chiral Amine
Author(s) -
Kano Taichi,
Mii Haruka,
Maruoka Keiji
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002965
Subject(s) - amine gas treating , chemistry , catalysis , metal , combinatorial chemistry , organic chemistry
And I'm free, metal‐free fallin' : A metal‐free direct asymmetric aminoxylation of aldehydes with the oxoammonium salt 1 , generated in situ from TEMPO and benzoyl peroxide (BPO), was found to be catalyzed by a binaphthyl‐based secondary amine ( S )‐ 2 . This method provides a new approach to bench‐stable optically active α‐aminoxy aldehydes as useful chiral building blocks. TMS=trimethylsilyl.
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