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A Direct Ylide Transfer to Carbonyl Derivatives and Heteroaromatic Compounds
Author(s) -
Huang Xueliang,
Goddard Richard,
Maulide Nuno
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002919
Subject(s) - ylide , sulfonium , reactivity (psychology) , methylene , chemistry , variety (cybernetics) , transfer (computing) , organic chemistry , combinatorial chemistry , computer science , parallel computing , medicine , salt (chemistry) , alternative medicine , pathology , artificial intelligence
Power transfer : The title reaction proceeds under mild conditions (room temperature, short reaction times) and directly affords sulfonium ylides from active methylene compounds and heteroaromatics in a single step and in high yields. A detailed comparative structural analysis of a variety of ylides is presented and the implications of structure on the reactivity of these compounds are discussed.