Asymmetric Conjugate Silyl Transfer in Iterative Catalytic Sequences: Synthesis of the C7–C16 Fragment of (+)‐Neopeltolide | Zendy

Hartmann Eduard | Zendy; Oestreich Martin | Zendy

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Asymmetric Conjugate Silyl Transfer in Iterative Catalytic Sequences: Synthesis of the C7–C16 Fragment of (+)‐Neopeltolide

Author(s) -

Hartmann Eduard,

Oestreich Martin

Publication year - 2010

Publication title -

angewandte chemie international edition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 5.831

H-Index - 550

eISSN - 1521-3773

pISSN - 1433-7851

DOI - 10.1002/anie.201002916

Subject(s) - conjugate , silylation , sequence (biology) , catalysis , fragment (logic) , combinatorial chemistry , chemistry , selectivity , stereochemistry , computer science , algorithm , mathematics , organic chemistry , biochemistry , mathematical analysis

Matched or mismatched, that is not the question! The anti , anti configuration of the C7–C16 fragment of (+)‐neopeltolide is stereoselectively installed in an iterative sequence of catalyst‐controlled Si group and Me group transfers, even with mismatched selectivity in the former ( Si =Me 2 PhSi, see scheme; TBS= tert ‐butyldimethylsilyl).

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