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Asymmetric Conjugate Silyl Transfer in Iterative Catalytic Sequences: Synthesis of the C7–C16 Fragment of (+)‐Neopeltolide
Author(s) -
Hartmann Eduard,
Oestreich Martin
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002916
Subject(s) - conjugate , silylation , sequence (biology) , catalysis , fragment (logic) , combinatorial chemistry , chemistry , selectivity , stereochemistry , computer science , algorithm , mathematics , organic chemistry , biochemistry , mathematical analysis
Matched or mismatched, that is not the question! The anti , anti configuration of the C7–C16 fragment of (+)‐neopeltolide is stereoselectively installed in an iterative sequence of catalyst‐controlled Si group and Me group transfers, even with mismatched selectivity in the former ( Si =Me 2 PhSi, see scheme; TBS= tert ‐butyldimethylsilyl).