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Organocatalytic Asymmetric Inverse‐Electron‐Demand Diels–Alder Reaction of Electron‐Deficient Dienes and Crotonaldehyde
Author(s) -
Li JunLong,
Kang TaiRan,
Zhou SiLi,
Li Rui,
Wu Li,
Chen YingChun
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002912
Subject(s) - crotonaldehyde , regioselectivity , chemistry , cyclohexene , trimethylsilyl , catalysis , diels–alder reaction , organic chemistry , medicinal chemistry
Another pathway for enals : The excellent β,γ‐regioselectivity shown in the title reaction under dienamine catalysis efficiently gave highly diastereo‐ and enantioenriched cyclohexene derivatives with substantial substitution diversity (see scheme; EWG=electron‐withdrawing group, TMS=trimethylsilyl).