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Proof of RNA Interference in Humans after Systemic Delivery of siRNAs
Author(s) -
Kurreck Jens
Publication year - 2010
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/anie.201002867
Subject(s) - small interfering rna , rna interference , rna , chemistry , messenger rna , polyethylene glycol , adamantane , microbiology and biotechnology , biology , gene , biochemistry , organic chemistry
Great hope is placed in the use of RNA interference in the development of novel therapeutics. Recently, small interfering RNAs (siRNAs) were delivered to tumor cells of melanoma patients by nanoparticles consisting of a cyclodextrin polymer, and polyethylene glycol coupled to adamantane and transferrin (see picture). It was demonstrated that the target mRNA in the patients was degraded by a specific RNA interference mechanism.